Aflatoxins are the best known group of mycotoxins produced as secondary metabolites by fungi, mainly by Aspergillus flavus and Aspergillus parasiticus, but to a smaller extent also by other strains. This origin is also where the name Aspergillus flavus toxin comes from. Aflatoxins can be produced on crops in the field or during storage of agricultural products, especially under warm conditions and high humidity. Unfortunately, these substances can persist long after the fungi have been killed and therewith contaminate foods. Most mycotoxins are stable compounds that are also not destroyed during food processing or cooking.

Since they can easily enter the marketplace and be a hazard to public health it is important to develop effective analytical methods for the identification and quantification of mycotoxins. Governmental institutions and health protection agencies apply these methods on a large scale to control marketed food products and animal feed. In the food processing industry the same methods are used to check raw materials and products, in order to direct them to countries with an appropriate legislation.

The “AZURA® Aflatoxin System“ includes:

• AZURA Autosampler AS 6.1L for automatted sample injection
• AZURA Pump P 6.1L low pressure gradient pump with maximum pressure of 700 bar
• AZURA Column thermostat  CT 2.1 for column tempering and reproducible results
• Fluorescence detector RF-20A coupled to a photochemical postcolumn derivatization reactor for sensitive detection of aflatoxins
• Sample preparation kit consisting of SPE cartridges and method protocol
• Application description including method and analytical HPLC column

The system is controled with ClarityChrom® software. Additionally, a tablet PC with AZURA Mobile Control to monitor the system status and for direct control can be used.

Technical Data

The post AZURA Aflatoxin System appeared first on Icon Scientific Inc..

Carbohydrates, alcohols, and organic acids are important in the manufacture of many foods, pharmaceuticals, and biofuels. This dedicated system is specially designed to separate and analyze these compounds. The heart of this system is the superior AZURA refractive index detector RID 2.1L with an outstanding linear range and sensitivity. More systems components are the column thermostat CT 2.1 and the isocratic AZURA pump P 6.1L for delivery of small flow rates (0.001 -10 ml/min) and pressure up to 700 bar. This price attractive system is developed to run simple and rapid methods that enable simultaneous determination of sugars, organic acids and alcohols. Therefore, an interesting application is the analysis of all major wine compounds (see our application note) for quality control.

Technical Data

The post AZURA System for Sugar Analysis appeared first on Icon Scientific Inc..

The AZURA Compact HPLC isocratic educational system is a small complete analytical isocratic HPLC system. Due to its compact dimensions, the system fits onto every laboratory bench. The AZURA Compact HPLC isocratic is based on the multifunctional AZURA element ASM 2.1L and contains two integrated modules and a manual injecton valve, that is fixed to the side of the system. The integrated modules are a pump and a UV/VIS detector with one variable wavelength. A flow cell is included in the package. The system comes with an eluent tray for safe storage of up to six bottles. The column can be attached anywhere to the system via magnetic clip. A leak sensor and the capillary guidance as well as the optional

AZURA Mobile Control facilitate the safe and user friendly operation. The stackable elements of AZURA allow to create complex system solutions requiring a only minimum of space. Modern design with completely demountable fronts turn the system into a visual highlight.

Key Features

• Complete isocratic analytical HPLC system that needs very little bench space
• UV/VIS detector with one variable wavelength
• Pump unit with pressure sensor for a low pulsation eluent supply
• Optional AZURA Mobile Control App allows direct control of all integrated modules
• Leakage protection
• Complete software package ClarityChrom® (Educational Licence)
• Notebook
• Capillary scheme
• Application note
• Introduction to operation of software and hardware via short movies

Technical Data

The post AZURA Educational system appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L HPG/LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a MWD or DAD 2.1L UV/VIS detector with 8-variable UV measuring channels from 190 – 750 nm, as well as a Tablet PC with AZURA Mobile Control. It is the standard system with a backpressure range of 700 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a HPG configuration features a solvent selection valve to set up to 4 solvents to the system of which two can be blended simultaneously. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The DAD 2.1L features a novel light path and flow cell architecture with improved handling and excellent performance. The frontal lamp and cell change ensures easy and secure maintenance. The temperature controlled optical bench minimizes signal drift. The wide flow cell selection allows the DAD 2.1L to be easily adapted to your needs.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is the new price attractive basic column thermostat. It is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key Features

• Complete gradient analytical HPLC system
• Variable multichannel UV/VIS Detector (or DAD)
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 700 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Introduction to operation of software and hardware via short movies
• Complete software package ClarityChrom®
• Leakage protection
• PC with Monitor
• Tubing scheme
• Application note

Technical Data

The post AZURA HPLC Plus System appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L HPG/LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a DAD 2.1L UV/VIS detector with 8-variable UV measuring channels from 190 – 750 nm, as well as a Tablet PC with AZURA Mobile Control. It is the standard system with a backpressure range of 700 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a HPG configuration features a solvent selection valve to set up to 4 solvents to the system of which two can be blended simultaneously. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The DAD 2.1L features a novel light path and flow cell architecture with improved handling and excellent performance. The frontal lamp and cell change ensures easy and secure maintenance. The temperature controlled optical bench minimizes signal drift. The wide flow cell selection allows the DAD 2.1L to be easily adapted to your needs.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is the new price attractive basic column thermostat. It is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key Features

• Complete gradient analytical HPLC system
• Variable multichannel UV/VIS Detector (or DAD)
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 700 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Complete software package ClarityChrom®
• Leakage protection
• PC with Monitor
• Tubing scheme
• Application note

Technical Data

The post AZURA HPLC Plus System appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L HPG/LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a UVD 2.1L UV/VIS detector with 1-variable UV measuring channels from 190 – 750 nm, as well as a Tablet PC with AZURA Mobile Control. It is the standard system with a backpressure range of 700 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a HPG configuration features a solvent selection valve to set up up to 4 solvents to the system of which two can be blended simultaneously. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The UVD 2.1L comes with an installed deuterium lamp which covers a wavelength range from 190 to 750 nm. It is a competitively priced HPLC for routine HPLC applications including fast LC methods.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key Features

• Complete gradient analytical HPLC system
• Variable single wavelength 1-channel UV/VIS Detector
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 700 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Complete software package ClarityChrom®
• Leakage protection
• PC with Monitor
• Tubing scheme
• Application note

Technical Data

The post AZURA HPLC Plus System appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L HPG/LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a UVD 2.1L UV/VIS detector with 1-variable UV measuring channels from 190 – 750 nm, as well as a Tablet PC with AZURA Mobile Control. It is the standard system with a backpressure range of 700 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a LPG configuration features a new LPG valve for the most reise blending effciency. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The UVD 2.1L comes with an installed deuterium lamp which covers a wavelength range from 190 to 750 nm. It is a competitively priced HPLC for routine HPLC applications including fast LC methods.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key Features

• Complete gradient analytical HPLC system
• Variable single wavelength 1-channel UV/VIS Detector
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 700 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Complete software package ClarityChrom
• Leakage protection
• PC with Monitor
• Tubing scheme
• Application note

Technical Data

The post AZURA HPLC Plus System appeared first on Icon Scientific Inc..

The AZURA® HPLC Compact iso is a small complete analytical isocratic HPLC system. Due to its compact dimensions, the system fits onto every laboratory bench.
The system is based on the multifunctional AZURA® Assistant ASM 2.1L and contains three integrated modules. An AZURA® Detector UVD 2.1S, an AZURA® Pump P 4.1S and a electric injection valve.

The system comes with an eluent tray for safe storage of up to 6 bottles. A leak sensor and the tubing guidance as well as the Mobile Control unit with touch screen, facilitate the safe and user friendly usage. Modern design with completely demountable fronts turn the system into a visual highlight.

The column thermostat AZURA® CT 2.1 is suitable for column thermostatization above and below room temperature.
The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key Features

• Complete isocratic analytical HPLC system that needs very little bench space
• UV/VIS detector with one variable wavelength
• RI detection with temperature controlled optical bench
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 400 bar)
• Mobile Control unit allows direct control and data recording of all integrated modules
• Complete software package Mobile Control
• PC with monitor and ClarityChrom® software
• Tubing scheme
• Leakage protection

Technical Data

The post AZURA HPLC Compact isocratic (with UV and RI detection) appeared first on Icon Scientific Inc..

The AZURA® HPLC Compact iso is a small complete analytical isocratic HPLC system. Due to its compact dimensions, the system fits onto every laboratory bench.
The system is based on the multifunctional AZURA® Assistant ASM 2.1L and contains three integrated modules; an AZURA® Detector UVD 2.1S, an AZURA® Pump P 4.1S and a electric injection valve

The system comes with an eluent tray for safe storage of up to 6 bottles. The column can be attached anywhere to the system via magnetic clip. A leak sensor and the tubing guidance as well as the Mobile Control unit with touch screen, ensure the safe and user friendly usage. Modern design with completely demountable fronts turn the system into a visual highlight.

Key Features

• Complete isocratic analytical HPLC system that needs very little bench space
• UV/VIS detector with one variable wavelength
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 400 bar)
• Mobile Control Chrom allows direct control and data recording of all integrated modules
• Leakage protection
• Complete software package Mobile Control
• Tubing scheme

Technical Data

The post AZURA HPLC Compact isocratic (with UV detection) appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L HPG/LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a MWD or DAD 2.1L UV/VIS detector with 8-variable UV measuring channels from 190 – 750 nm, as well as a Tablet PC with AZURA Mobile Control. It is the standard system with a backpressure range of 700 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a LPG configuration features a new LPG valve for the most reise blending effciency. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The DAD 2.1L features a novel light path and flow cell architecture with improved handling and excellent performance. The frontal lamp and cell change ensures easy and secure maintenance. The temperature controlled optical bench minimizes signal drift. The wide flow cell selection allows the DAD 2.1L to be easily adapted to your needs.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is the new price attractive basic column thermostat. It is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key Features

• Complete gradient analytical HPLC system
• Variable multichannel UV/VIS Detector (or DAD)
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 700 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Complete software package ClarityChrom®
• Leakage protection
• PC with Monitor
• Tubing scheme
• Application note

Technical Data

The post AZURA HPLC Plus System appeared first on Icon Scientific Inc..

This gradient HPLC system perfectly meets even sophisticated analysis demands, robustness and quality “Made in Germany”. The system features a low pressure gradient pump for up to 700 bar, an autosampler, column thermostat and a diode array detector with 8 channels and a wavelength range from 190 – 700 nm.

In the monitoring of industrial air, the determination of carbonyl (aldehyde and ketone) emissions is crucial to prevent respiratory, pulmonological, autoimmune diseases, and cancer. According to the analytical method described in the DIN ISO 16000-3 [1], the carbonyls must be converted to their corresponding hydrazones with 2,4-dinitrophenylhydrazin (DNPH) in order to be detected via UV detector and analyzed by reversed phase HPLC. Here, the DryLab® software was used for method optimization to separate of 13 carbonyl derivatives in a standard mixture with the AZURA® HPLC system and the DNPH-column. The main objective of method optimization in HPLC is to define the appropriate conditions for robust, precise, and reproducible analysis. In order to save resources, a computer assisted method development can be a valuable tool. For the characterization of carbonyl content in air samples, commonly a standard mixture of 13 aldehyde and ketone DNPH derivatives is used. For precise analysis a good separation of all 13 components has to be achieved. Here, the chromatography modelling software DryLab® with 3D Cube option was used for the optimization of the analysis of the cabonyl standard mixture. The investigation of the combined influence of gradient time, temperature and ternary eluent composition on critical resolution enabled the development of robust method conditions. Furthermore, the robustness space was investigated in silico and verified experimentally with a high degree of agreement.

For data acquisition and analysis, the system can be operated with the software packages ClarityChrom®*, OpenLAB® EZChrom Edition, or Chromeleon®.

Special system – Contact us!
Offer valid until December 31st, 2018

A chromatography data system or DryLab® software are not included in the offer.
In addition, you can order the system installation, maintenance and training by our KNAUER experts.

Technical Data

The post HPLC system for the analysis of carbonyl emissions in air – special system offer appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a DAD 6.1L UV/VIS detector with 8-variable UV measuring channels from 190 – 1000 nm, as well as a Tablet PC with AZURA Mobile Control.It is the UHPLC system with a backpressure range of 1000 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a HPG configuration features a solvent selection valve to set up to 4 solvents to the system of which two can be blended simultaneously. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The DAD 2.1L features a novel light path and flow cell architecture with improved handling and excellent performance. The frontal lamp and cell change ensures easy and secure maintenance. The temperature controlled optical bench minimizes signal drift. The wide flow cell selection allows the DAD 2.1L to be easily adapted to your needs.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is the new price attractive basic column thermostat. It is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key features

• Complete gradient analytical HPLC system
• Variable multichannel UV/VIS Detector (or DAD)
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 1000 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Complete software package ClarityChrom
• Mobile Control for maintenance and diagnostics
• Leakage protection
• PC with Monitor

Technical Data

The post AZURA UHPLC System appeared first on Icon Scientific Inc..

This system features a AZURA P 6.1L LPG pump, an Autosampler 6.1L, a column thermostat CT 2.1, a DAD 6.1L UV/VIS detector with 8-variable UV measuring channels from 190 – 1000 nm, as well as a Tablet PC with AZURA Mobile Control.It is the UHPLC system with a backpressure range of 1000 bar. It perfectly fits the demanding needs of a method development system, as well as the robust fitness of a routine analysis machine.

The P6.1L with a LPG configuration features a new LPG valve for the most precise blending effciency. The internal degassing unit will prevent air bubbles in the system. Every P 6.1L comes with an attached mixing chamber, which can be changed to a larger volume depending on the applications needs.

The DAD 2.1L features a novel light path and flow cell architecture with improved handling and excellent performance. The frontal lamp and cell change ensures easy and secure maintenance. The temperature controlled optical bench minimizes signal drift. The wide flow cell selection allows the DAD 2.1L to be easily adapted to your needs.

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

The AZURA CT 2.1 is the new price attractive basic column thermostat. It is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Key features

• Complete gradient analytical HPLC system
• Variable multichannel UV/VIS Detector (or DAD)
• Pump unit with pressure sensor for a low pulsation eluent supply (max. 1000 bar)
• AZURA Mobile Control unit allows direct control of all integrated modules
• Complete software package ClarityChrom
• Mobile Control for maintenance and diagnostics
• Leakage protection
• PC with Monitor

Technical Data

The post AZURA UHPLC System appeared first on Icon Scientific Inc..

This dedicated system is specifically designed for solid phase extraction (SPE) in combination with a powerful analytical KNAUER AZURA HPLC system.

Our versatile Assistant Module ASM 2.1L with two switching valves V 2.1S and a pump P 4.1S enables an efficient online SPE to concentrate analytes prior to HPLC analysis. This results in the reduction of analysis time and sample contamination as well as in an increase of analyte yield.

Afterward, separation and analysis can be achieved with a classical KNAUER AZURA analytical system equipped with P 6.1L LPG pump, a column thermostat CT 2.1 and a multiwavelengths detector MWD 2.1L to detect up to eight different wavelengths simultaneously.

This combination allows very sensitive determination of low concentrated samples and extracts e.g. bisphenol A (BPA) from water samples.

Technical Data

The post AZURA Online SPE System appeared first on Icon Scientific Inc..