Centrifugal Partition Chromatography

Centrifugal Partition Chromatography is a better way to purify cannabinoids. CPC is a technique that is used to separate similar substances in the mixture based on their differing partition coefficients. Centrifugal partition chromatography (CPC) is a preparative liquid chromatography method. CPC can easily be scaled up to process and industrial levels. Centrifugal Partition Chromatography is a superior method for purifying CBD and other cannabis extracts.

CPC is different from traditional process HPLC and flash chromatography because it does not have a silica solid phase. Traditional high pressure liquid chromatography (HPLC) uses a solid stationary phase and a solvent as the mobile phase. In Counter Current Chromatography (CCC) both phases are liquid. CCC includes both types of liquid-liquid chromatography. CCC includes hydrodynamic CCC and hydrostatic CCC. Hydrostatic CCC is also referred to as Centrifugal Partition Chromatography and is based on the principle of liquid-liquid partitioning.

Centrifugal Partition Chromatography (CPC) is a unique chromatographic technique where both the stationary and the mobile phase use two solvents that are immiscible. It is called Centrifugal Partition Chromatography because the stationary phase is held in place by a strong centrifugal force of a spinning rotor, while the mobile phase is pumped through the column. Partition refers to the solutes being partitioned in both liquid phases according to their relative solubility in each phase. In Centrifugal Partition Chromatography, the Rotary movement of the column rotates around a single axis. The rotor design gives CPC enormous separation potential. Elution is determined by the affinity for the mobile phase. Molecules with greater affinity for the mobile phase elute first. Molecules with greater affinity for the stationary phase elute later. CPC systems can work in both ascending and descending modes. If the lighter phase is the mobile phase it is the ascending mode. If the heavier phase is the mobile phase it is the descending mode. This concept allows purification similar to normal and reverse phase modes in traditional chromatography, without replacing the column.

It is important to understand that the CPC rotor serves the same role as a traditional HPLC column would serve. Each system also requires preparative HPLC pumps, UV detectors, fraction collection capability, valves and preparative chromatography software.

There are many different chromatography based techniques available to the cannabis and hemp industry. While traditional preparative high pressure liquid chromatography (HPLC) and flash chromatography seems to be the obvious method for purification of cannabinoids, they may not be the most efficient choice. Centrifugal Partitioning Chromatography is used to separate, identify and quantify the chemical components of a mixture, such as cannabis or hemp. CCC and CPC offers the end user many advantages over traditional HPLC methods. Countercurrent Chromatography has been used to purify natural products for over 50 years. Below are the benefits of Counter Current Chromatography (CCC) and High Performance Centrifugal Partition Chromatography (HPCPC):

1. Highest yields typically 90 to 95%
2. No solid support to purchase or dispose of
3. No irreversible binding as with prep HPLC or flash chromatography, because there is no solid phase to bind to
4. Purity of almost 100%
5. Lower operating cost compared to prep HPLC and flash chromatography because there is no solid phase to purchase or replenish.
6. No degradation in efficiency from run to run
7. Reduced run times
8. Easier to scale than traditional liquid chromatography
9. Significantly higher loading volumes compared to flash or prep HPLC
10. Typical injection loading 10% of coil volume
11. Pesticides are removed in the purification process
12. No risk of a blocked or contaminated column
13. Pure fractions of major and minor cannabinoids from a crude mixture as well as terpenes, alkaloids, flavonoids and other compounds
14. CPC is capable of purifying cannabinoids in the purest form enabling THC free CBD
15. High injection capacity
16. CPC columns typically use about 20% of the solvent used for traditional columns
17. Solvents can be recycled for additional savings
18. CPC columns do not need to be replaced like preparative HPLC or flash columns

While HPLC is the industry standard for cannabinoid potency testing, CPC will likely become the gold standard for purification of cannabinoids. There are a couple of drawbacks to CPC purifications. The first is that most purification specialists are unfamiliar with the technology. The second limitation is that most chromatographers are unfamiliar with how to optimize CPC for cannabinoid purifications. Partnering with Icon Scientific you will overcome both of these obstacles. Our Technical Support group has extensive expertise and will guarantee your purification success.

The post Process System HPCPC appeared first on Icon Scientific Inc..

Can operate in a standard lab

Centrifugal Partition Chromatography

Centrifugal Partition Chromatography is a better way to purify cannabinoids. CPC is a technique that is used to separate similar substances in the mixture based on their differing partition coefficients. Centrifugal partition chromatography (CPC) is a preparative liquid chromatography method. CPC can easily be scaled up to process and industrial levels. Centrifugal Partition Chromatography is a superior method for purifying CBD and other cannabis extracts.

CPC is different from traditional process HPLC and flash chromatography because it does not have a silica solid phase. Traditional high pressure liquid chromatography (HPLC) uses a solid stationary phase and a solvent as the mobile phase. In Counter Current Chromatography (CCC) both phases are liquid. CCC includes both types of liquid-liquid chromatography. CCC includes hydrodynamic CCC and hydrostatic CCC. Hydrostatic CCC is also referred to as Centrifugal Partition Chromatography and is based on the principle of liquid-liquid partitioning.

Centrifugal Partition Chromatography (CPC) is a unique chromatographic technique where both the stationary and the mobile phase use two solvents that are immiscible. It is called Centrifugal Partition Chromatography because the stationary phase is held in place by a strong centrifugal force of a spinning rotor, while the mobile phase is pumped through the column. Partition refers to the solutes being partitioned in both liquid phases according to their relative solubility in each phase. In Centrifugal Partition Chromatography, the Rotary movement of the column rotates around a single axis. The rotor design gives CPC enormous separation potential. Elution is determined by the affinity for the mobile phase. Molecules with greater affinity for the mobile phase elute first. Molecules with greater affinity for the stationary phase elute later. CPC systems can work in both ascending and descending modes. If the lighter phase is the mobile phase it is the ascending mode. If the heavier phase is the mobile phase it is the descending mode. This concept allows purification similar to normal and reverse phase modes in traditional chromatography, without replacing the column.

It is important to understand that the CPC rotor serves the same role as a traditional HPLC column would serve. Each system also requires preparative HPLC pumps, UV detectors, fraction collection capability, valves and preparative chromatography software.

There are many different chromatography based techniques available to the cannabis and hemp industry. While traditional preparative high pressure liquid chromatography (HPLC) and flash chromatography seems to be the obvious method for purification of cannabinoids, they may not be the most efficient choice. Centrifugal Partitioning Chromatography is used to separate, identify and quantify the chemical components of a mixture, such as cannabis or hemp. CCC and CPC offers the end user many advantages over traditional HPLC methods. Countercurrent Chromatography has been used to purify natural products for over 50 years. Below are the benefits of Counter Current Chromatography (CCC) and High Performance Centrifugal Partition Chromatography (HPCPC):

1. Highest yields typically 90 to 95%
2. No solid support to purchase or dispose of
3. No irreversible binding as with prep HPLC or flash chromatography, because there is no solid phase to bind to
4. Purity of almost 100%
5. Lower operating cost compared to prep HPLC and flash chromatography because there is no solid phase to purchase or replenish.
6. No degradation in efficiency from run to run
7. Reduced run times
8. Easier to scale than traditional liquid chromatography
9. Significantly higher loading volumes compared to flash or prep HPLC
10. Typical injection loading 10% of coil volume
11. Pesticides are removed in the purification process
12. No risk of a blocked or contaminated column
13. Pure fractions of major and minor cannabinoids from a crude mixture as well as terpenes, alkaloids, flavonoids and other compounds
14. CPC is capable of purifying cannabinoids in the purest form enabling THC free CBD
15. High injection capacity
16. CPC columns typically use about 20% of the solvent used for traditional columns
17. Solvents can be recycled for additional savings
18. CPC columns do not need to be replaced like preparative HPLC or flash columns

While HPLC is the industry standard for cannabinoid potency testing, CPC will likely become the gold standard for purification of cannabinoids. There are a couple of drawbacks to CPC purifications. The first is that most purification specialists are unfamiliar with the technology. The second limitation is that most chromatographers are unfamiliar with how to optimize CPC for cannabinoid purifications. Partnering with Icon Scientific you will overcome both of these obstacles. Our Technical Support group has extensive expertise and will guarantee your purification success.

The post Pilot System appeared first on Icon Scientific Inc..

2,3 or 4 coils per instrument

Centrifugal Partition Chromatography

Centrifugal Partition Chromatography is a better way to purify cannabinoids. CPC is a technique that is used to separate similar substances in the mixture based on their differing partition coefficients. Centrifugal partition chromatography (CPC) is a preparative liquid chromatography method. CPC can easily be scaled up to process and industrial levels. Centrifugal Partition Chromatography is a superior method for purifying CBD and other cannabis extracts.

CPC is different from traditional process HPLC and flash chromatography because it does not have a silica solid phase. Traditional high pressure liquid chromatography (HPLC) uses a solid stationary phase and a solvent as the mobile phase. In Counter Current Chromatography (CCC) both phases are liquid. CCC includes both types of liquid-liquid chromatography. CCC includes hydrodynamic CCC and hydrostatic CCC. Hydrostatic CCC is also referred to as Centrifugal Partition Chromatography and is based on the principle of liquid-liquid partitioning.

Centrifugal Partition Chromatography (CPC) is a unique chromatographic technique where both the stationary and the mobile phase use two solvents that are immiscible. It is called Centrifugal Partition Chromatography because the stationary phase is held in place by a strong centrifugal force of a spinning rotor, while the mobile phase is pumped through the column. Partition refers to the solutes being partitioned in both liquid phases according to their relative solubility in each phase. In Centrifugal Partition Chromatography, the Rotary movement of the column rotates around a single axis. The rotor design gives CPC enormous separation potential. Elution is determined by the affinity for the mobile phase. Molecules with greater affinity for the mobile phase elute first. Molecules with greater affinity for the stationary phase elute later. CPC systems can work in both ascending and descending modes. If the lighter phase is the mobile phase it is the ascending mode. If the heavier phase is the mobile phase it is the descending mode. This concept allows purification similar to normal and reverse phase modes in traditional chromatography, without replacing the column.

It is important to understand that the CPC rotor serves the same role as a traditional HPLC column would serve. Each system also requires preparative HPLC pumps, UV detectors, fraction collection capability, valves and preparative chromatography software.

There are many different chromatography based techniques available to the cannabis and hemp industry. While traditional preparative high pressure liquid chromatography (HPLC) and flash chromatography seems to be the obvious method for purification of cannabinoids, they may not be the most efficient choice. Centrifugal Partitioning Chromatography is used to separate, identify and quantify the chemical components of a mixture, such as cannabis or hemp. CCC and CPC offers the end user many advantages over traditional HPLC methods. Countercurrent Chromatography has been used to purify natural products for over 50 years. Below are the benefits of Counter Current Chromatography (CCC) and High Performance Centrifugal Partition Chromatography (HPCPC):

1. Highest yields typically 90 to 95%
2. No solid support to purchase or dispose of
3. No irreversible binding as with prep HPLC or flash chromatography, because there is no solid phase to bind to
4. Purity of almost 100%
5. Lower operating cost compared to prep HPLC and flash chromatography because there is no solid phase to purchase or replenish.
6. No degradation in efficiency from run to run
7. Reduced run times
8. Easier to scale than traditional liquid chromatography
9. Significantly higher loading volumes compared to flash or prep HPLC
10. Typical injection loading 10% of coil volume
11. Pesticides are removed in the purification process
12. No risk of a blocked or contaminated column
13. Pure fractions of major and minor cannabinoids from a crude mixture as well as terpenes, alkaloids, flavonoids and other compounds
14. CPC is capable of purifying cannabinoids in the purest form enabling THC free CBD
15. High injection capacity
16. CPC columns typically use about 20% of the solvent used for traditional columns
17. Solvents can be recycled for additional savings
18. CPC columns do not need to be replaced like preparative HPLC or flash columns

While HPLC is the industry standard for cannabinoid potency testing, CPC will likely become the gold standard for purification of cannabinoids. There are a couple of drawbacks to CPC purifications. The first is that most purification specialists are unfamiliar with the technology. The second limitation is that most chromatographers are unfamiliar with how to optimize CPC for cannabinoid purifications. Partnering with Icon Scientific you will overcome both of these obstacles. Our Technical Support group has extensive expertise and will guarantee your purification success.

The post Lab System appeared first on Icon Scientific Inc..

This AZURA Lab SMB System is optimized for very challenging multicolumn separation of binary mixtures of smal molecules in several hundred mg scale. The SMB System A29002 is the only ultra high pressure SMB System on the market. It consists of seven 6-multiposition valves and four AZURA P 4.1S included in four Assitants ASM 2.1L.* The high pressure range up to 400 bar allows to use column material down to 3 µm. Addionally it is possible to heat the columns up to 60°C. Running this system in an 3-Zone process allows you to succeed in even the most difficult separation tasks for small molecules. This system is not optimized for the separation of biomolecules or standard separations of binary mixures of small molecules. Therefore have a look at our AZURA® SMB Lab System

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

KNAUER MCCP

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs.
The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.
System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW)
Heating and column organisation: A29900 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)
Batch-Ugrade: A29601 (stainless steel), A29600 (bio-compatible)

Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.**

* Columns and the AZURA Click (A70089 + accesory) are not included. **additional equipment required

Technical Data

The post AZURA Lab SMB System appeared first on Icon Scientific Inc..

The AZURA Lab SMB System is optimized for the multicolumn separation of binary mixtures of small or biomolecules in gram-scale. The SMB System A29001 is the standard stainless steel configuration of our AZURA Lab SMB. It consists of seven 8-multiposition valves and four AZURA P 4.1S included in four Assitants ASM 2.1L.* The high pressure and temperature range as well as the flexibility of the multiposition valves make this system the perfect solution for classical SMB chromatography for low and high temperature applications.

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

KNAUER MCCP

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs.
The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.
System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW)
Heating and column organisation: A29900 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)
Batch-Ugrade: A29601 (stainless steel), A29600 (bio-compatible)

Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.**

* Columns and the AZURA Click (A70089 + accesory) are not included. **additional equipment required

Technical Data

The post AZURA Lab SMB System appeared first on Icon Scientific Inc..

The AZURA Pilot SMB System A29505 is optimized for the separation of binary mixtures in gram to several hundred gram-scale. Its special emphasis is put on the continuous operation mode and high productivity. The system configuration consists of four Pump 2.1L and seven 12-port multiposition valves integrated into four AZURA Assistans ASM 2.1L. Our user friendly software PurityChrom® MCC and the required IT hardware are included too. Due to the high number of integratable columns, this system is the perfect solution for SMB separations of small molecules, whenever the separation process has to be optimzied very accurate as well as for challenging capture protein purification. A maximum pressure of 25 bar, 12 columns and a flowrate of up to 500 ml/min allows you to do a separation on columns up to 50 mm ID.

Choose your operation mode!

With our SMB-Systems you can easily switch between different operation modes:

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

Capture SMB

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs. Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.* The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

Technical Data

The post AZURA® Pilot SMB System appeared first on Icon Scientific Inc..

The AZURA Pilot SMB System A29503 is optimized for the separation of binary mixtures in gram to several hundred gram-scale. Its special emphasis is put on the continuous operation mode and high productivity. The system configuration consists of four Pump 2.1L and seven 16-port multiposition valves integrated into four AZURA Assistans ASM 2.1L. Our user friendly software PurityChrom® MCC and the required IT hardware are included too. Due to the high number of integratable columns, this system is the perfect solution for SMB separations of small molecules, whenever the separation process has to be optimzied very accurate as well as for challenging capture protein purification. A maximum pressure of 50 bar, 16 columns and a flowrate of up to 100 ml/min allows you to do a separation on columns up to 30 mm ID.

Choose your operation mode!

With our SMB-Systems you can easily switch between different operation modes:

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

Capture SMB

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs. Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.* The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

Technical Data

The post AZURA® Pilot SMB System appeared first on Icon Scientific Inc..

The AZURA Lab SMB System is optimized for the multicolumn separation of binary mixtures of small or biomolecules in gram-scale. The SMB System A29003 is the a stainless steel configuration of our AZURA Lab SMB. It consists of seven 16-multiposition valves and four AZURA P 4.1S included in four Assitants ASM 2.1L. The 16-column configuration allows you to adjust your zone definition during your smb process very flexible to find the perfect configuration for your separation. This configuration can be very helpfull to do be succesfull with challenging capture smb processes as well. Be aware, this is a very special configuration. If you are interested in a classical SMB system, please have a look at our AZURA Lab SMB A29000 with standard configuration.

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

KNAUER MCCP

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs.
The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.
System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW)
Heating and column organisation: A29900 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)
Batch-Ugrade: A29601 (stainless steel), A29600 (bio-compatible)

Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.**

* Columns and the AZURA Click (A70089 + accesory) are not included. **additional equipment required

Technical Data

The post AZURA Lab SMB System appeared first on Icon Scientific Inc..

The AZURA Pilot SMB System A29504 is optimized for the separation of binary mixtures in gram to kilogram-scale. Its special emphasis is put on the continuous operation mode and high productivity. The system configuration consists of four Pump 2.1L and seven multiposition valves integrated into four AZURA Assistans ASM 2.1L. Our user friendly software PurityChrom® MCC and the required IT hardware are included too. This system is our standard Pilot SMB configuration and is optimized to bring success on a wide range of applications both the separation of smal molecules and the purification of proteins via capture SMB. A maximum pressure of 240 bar, eight columns and a flowrate of up to 100 ml/min allows you to do a separation on columns up to 30 mm ID.

Choose your operation mode!

With our SMB-Systems you can easily switch between different operation modes:

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

Capture SMB

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs. Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.* The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

Technical Data

The post AZURA® Pilot SMB System appeared first on Icon Scientific Inc..

The AZURA Pilot SMB System A29502 is optimized for the separation of binary mixtures in gram to several hundred gram-scale. The system configuration consists of four Pump 2.1L and seven 8-port multiposition valves integrated into four AZURA Assistans ASM 2.1L. Our user friendly software PurityChrom® MCC and the required IT hardware are included too. A maximum pressure of 344 bar, eight columns and a flowrate of up to 100 ml/min allows you to do a separation on columns typically up to 30 mm ID. Due to the high pressure range this system can be used with columns with small particle sizes and is the perfect system solution for challenging separation tasks. If you need a higher productivity, have a look at our AZURA® Pilot SMB System A29501

Choose your operation mode!

With our SMB-Systems you can easily switch between different operation modes:

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

Capture SMB

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs. Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.* The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

Technical Data

The post AZURA® Pilot SMB System appeared first on Icon Scientific Inc..

The AZURA Pilot SMB System A29501 is optimized for the separation of binary mixtures in gram to kilogram-scale. Its special emphasis is put on the continuous operation mode and high productivity. The system configuration consists of four Pump 2.1L and seven 8-port multiposition valves integrated into four AZURA Assistans ASM 2.1L. Our user friendly software PurityChrom® MCC and the required IT hardware are included too. This system is our standard Pilot SMB configuration and is optimized to bring success on a wide range of applications both the separation of smal molecules and the purification of proteins via capture SMB. A maximum pressure of 100 bar, eight columns and a flowrate of up to 500 ml/min allows you to do a separation on columns up to 50 mm ID.

Choose your operation mode!

With our SMB-Systems you can easily switch between different operation modes:

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

Capture SMB

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs. Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.* The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

Technical Data

The post AZURA® Pilot SMB System appeared first on Icon Scientific Inc..

The AZURA Lab SMB System is optimized for the multicolumn separation of binary mixtures of small or biomolecules in gram-scale. The SMB System A29000 is the standard configuration of our AZURA Lab SMB. It consists of seven 8-multiposition valves and four AZURA P 4.1S included in four Assitants ASM 2.1L.* The high pressure range and the biocompatibility as well as the flexibility of the multiposition valves make this system the perfect solution for classical SMB chromatography and for multi-column continuous processes (MCCP).

Classical SMB Chromatography

The standard configuration is designed to run classical SMB separations. You can easily switch between different zone configurations. To switch from a classical 2:2:2:2 to a 1:3:3:1 configuration you just need to click one button in our software PurityChrom MCC. Other configurations can be chosen too.

KNAUER MCCP

The flexible design of the SMB system allows you to run continuous FPLC purification after minor changes to the system. Use AZURA Lab SMB as your step to the future of biopurification and run your downstream process with the highest productivity and lowest costs.
The most flexible SMB System in the world Use a wide range of different upgrade options or just add a detector to build up a SMB chromatography system suits perfectly to your needs. Do you want to change the wetted parts? Contact us to get more information!

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.
System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW) Heating and column organisation: A29900 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)
Batch-Ugrade: A29601 (stainless steel), A29600 (bio-compatible)

Parallel Batch Chromatography Just add detectors to the the System and run batch runs parallel or use the system for single batch runs. You could use an eight column setup to run four separations parallel for example.**

* Columns and the AZURA Click (A70089 + accesory) are not included. **additional equipment required

Technical Data

The post AZURA Lab SMB System appeared first on Icon Scientific Inc..