Liquid Nanoparticles (LNP) – Icon Scientific Inc. https://www.iconsci.com Highest Quality Liquid Chromatography Products & Service Fri, 09 Jul 2021 18:47:55 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://www.iconsci.com/wp-content/uploads/2019/03/favicon.png Liquid Nanoparticles (LNP) – Icon Scientific Inc. https://www.iconsci.com 32 32 Customized Impingement jets mixing skids for Large Production Scale https://www.iconsci.com/shop/customized-impingement-jets-mixing-skids-for-large-production-scale/ Fri, 09 Jul 2021 18:42:56 +0000 https://www.iconsci.com/?post_type=product&p=4721 The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be […]

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]]> The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on the customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

 

The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • up to 16 KNAUER high-pressure dosing pumps 80P
  • up to 16 Coriolis flow meters
  • up to 8 KNAUER IJM mixers
  • Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
  • Outlet manifold for LNP solution
  • Back-seal washing system
  • The frame (stainless steel system 1.4301)
  • Installation & familiarization by KNAUER

 

 

Impingement Jets Mixing Skids Details

Number of impingement jets mixers up to 8
Number of pumps up to 16
Number of flow meter up to 16
Process connection inlet Sanitary Clamp Connector (2 Inlets)
Process connection outlet Sanitary Clamp Connector (1 Outlet)
Volumetric flow rate (L/min) depending on configuration
Volumetric flow rate (L/hour) depending on configuration
Maximum operation pressure 50-70 bar
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al2O3), ruby, sapphire
Software not included, necessary interfaces for the integration into PLC available
Interfaces Pump: LAN, RS-232, pin header connectors;
Flow meter: RS-232 + Industrial Interfaces;
Valve drive: LAN
Power supply Pump: 100–240 V, 50–60 Hz;
Flow meter: +15…24 V DC,
Maximum power consumption Values per device
Pump: maximum 320 W;
Flow meter: 3 W
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions depending on configuration
Weight depending on configuration
API-predilution and quenching depending on configuration
GMP-ready documentation YES
Factory acceptance test YES
Site acceptance test YES
Purchase order lead time minimum 5 months, depending on customer requirements
Disclaimer Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

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]]> Impingement jets mixing skid for Pilot Scale https://www.iconsci.com/shop/impingement-jets-mixing-skid-for-pilot-scale/ Fri, 09 Jul 2021 18:39:49 +0000 https://www.iconsci.com/?post_type=product&p=4719 The Impingement Jets Mixing (IJM) Pilot Scale Unit for high-flow production of nanoparticles (LNP, microemulsions, etc.) is the perfect choice for […]

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]]> The Impingement Jets Mixing (IJM) Pilot Scale Unit for high-flow production of nanoparticles (LNP, microemulsions, etc.) is the perfect choice for R&D purposes and small productions batches.

The unit contains of four pumps enabling all the steps from predilution of the Concentrated Active Pharmaceutical Ingredient (API), Impingement Jets Mixing of lipid and API phase and finally the quenching of the nanoparticle solution.

Furthermore the unit is equipped with four flowmeters for flow monitoring, one jets mixer and two mixers for predilution and quenching. Our CDS software provides an intuitive and easy operating of the IJM-SKID. The system visualization offers a graphical representation and allows easy handling of the complex flow processes. Additionaly, each device which is displayed in the fluidic scheme can be manually controlled, giving the opportunity to optimize, change and adapt your conditions also during the run. The software complies with 21 CFR Part 11.

The skid is built in a stainless steel frame on casters and are suitable for CIP cleaning procedure in pharmaceutical production.

 

The Impingement Jets Mixing (IJM) Pilot Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • 4 KNAUER high-pressure dosing pumps 80P
  • 4 Coriolis flow meters
  • 1 KNAUER IJM mixers
  • 2 Mixers
  • 8-port multiposition Valve
  • Inlet for Lipid and mRNA (Sanitary Clamp Connector)
  • Inlet for buffer (Sanitary Clamp Connector)
  • Outlet for LNP solution (Sanitary Clamp Connector)
  • Internal piping
  • Frame (stainless steel system 1.4301)
  • CDS software, 21 CFR part 11 compliant
  • Chromatography workstation with 27″ monitor
  • Installation & familiarization by KNAUER

 

 

Impingement Jets Mixing Skids Details

Number of impingement jets mixers 1
Number of pumps 4
Number of flow meter 4
Number of valves 1
Process connection inlet 1/2″ Tri-clamp (4 Inlets) – different connections on request
Process connection outlet 1/2“ Tri-clamp (1 Outlet) – different connections on request.
Volumetric flow rate (L/min) up to 1 liter/min
Volumetric flow rate (L/hour) up to 60 liter/h
Maximum operation pressure 100 bar
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al2O3), ruby, sapphire
Software CDS, 21 CFR part 11 compliant
Interfaces Pump: LAN, RS-232, pin header connectors;
Flow meter: RS-232 + FLOWBUS;
Valve drive: LAN
Power supply Pump: 100–240 V, 50–60 Hz;
Flow meter: +15…24 V DC,
Valve drive: 24 V DC
Maximum power consumption Values per device
Pump: maximum 320 W;
Flow meter: 3 W ;
Valve drive: 65 W
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions 900 x 915 x 700 mm
Weight ~ 150 kg
API-predilution and quenching YES
GMP-ready documentation YES
Factory acceptance test YES
Site acceptance test YES
Purchase order lead time about 3 months
Disclaimer Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

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]]> Impingement jets mixing skid for Small Production Scale https://www.iconsci.com/shop/impingement-jets-mixing-skid-for-small-production-scale/ Fri, 09 Jul 2021 18:37:34 +0000 https://www.iconsci.com/?post_type=product&p=4718 The Impingement Jets Mixing (IJM) Small Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) contains two parallel […]

The post Impingement jets mixing skid for Small Production Scale appeared first on Icon Scientific Inc..

]]> The Impingement Jets Mixing (IJM) Small Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) contains two parallel mixing units. Each unit consists of four pumps enabling all the steps from predilution of the Concentrated Active Pharmaceutical Ingredient (API), Impingement Jets Mixing of lipid and API phase, and finally the quenching of the nanoparticle solution. Furthermore, each unit is equipped with four flowmeters for flow monitoring, one jets mixer, and two mixers for predilution and quenching.

 

Knauer’s CDS software provides an intuitive and easy operating of the IJM-SKID. The system visualization offers a graphical representation and allows easy handling of the complex flow processes. Additionally, each device that is displayed in the fluidic scheme can be manually controlled. You have the opportunity to optimize, change and adapt your conditions also during the run. The software complies with 21 CFR Part 11.

All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

 

The Impingement Jets Mixing (IJM) Small Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • 8 KNAUER high-pressure dosing pumps 80P
  • 8 Coriolis flow meters
  • 2 Impingement jet mixers
  • 4 Mixers
  • 2 8-port multiposition Valve
  • Inlet for Lipid and mRNA (Sanitary Clamp Connector)
  • Inlet for citrate buffer (Sanitary Clamp Connector)
  • An outlet for LNP solution (Sanitary Clamp Connector)
  • Internal piping
  • Frame (Stainless Steel system 1.4301; 1000 x 1310 x 800 mm (WxHxD))
  • CDS software, 21 CFR part 11 compliant
  • Chromatography workstation with 27″ monitor

 

Impingement Jets Mixing Skids Details

Number of impingement jets mixers 4
Number of pumps 8
Number of flow meter 8
Number of valves 2
Process connection inlet 3/8″ and 1/4″ barbed fitting (6 Inlets) – different connections on request
Process connection outlet 1/4″ barbed fitting (2 Outlets) – different connections on request.
Volumetric flow rate (L/min) up to 2 liter/min
Volumetric flow rate (L/hour) up to 120 liter/h
Maximum operation pressure 100 bar
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al2O3), ruby, sapphire
Software CDS, 21 CFR part 11 compliant
Interfaces Pump: LAN, RS-232, pin header connectors;
Flow meter: RS-232 + FLOWBUS;
Valve drive: LAN
Power supply Pump: 100–240 V, 50–60 Hz;
Flow meter: +15…24 V DC,
Valve drive: 24 V DC
Maximum power consumption Values per device
Pump: maximum 320 W;
Flow meter: 3 W ;
Valve drive: 65 W
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions 1000 x 1290 x 700 mm
Weight ~ 250kg
API-predilution and quenching YES
GMP-ready documentation YES
Factory acceptance test YES
Site acceptance test YES
Purchase order lead time about 3 months
Disclaimer Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

The post Impingement jets mixing skid for Small Production Scale appeared first on Icon Scientific Inc..

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